你的位置:塑化剂专题首页 >> 其它媒体报道 >> 正文
普通输液器毒性塑化剂占四成
来源:首都医科大学附属北京胸科医院   时间:2012/12/27 8:59:47

被媒体广泛关注的食品塑化剂(又叫增塑剂)问题似乎已告一段落,然而我们的生活中塑化剂无处不在。普通PVC输液器中塑化剂(邻苯二甲酸二辛酯,DEHP)占近四成。

    DEHP以环境激素类毒性为主,主要影响机体内激素类物质的正常生理功能,干扰内分泌。 DEHP主要靶器官是睾丸、子宫、卵巢,影响性腺和生殖器官发育,可导致生殖系统发育不良、婴幼儿性别错乱、性早熟。DEHP还具有致畸、致癌性。
    PVC材料具有一定的硬度,制作输液器时通常加入30%-40%的增塑剂来增加其柔韧性。
    用PVC输液器输入一般药物时DEHP比较稳定,不会释放出来对人体造成伤害。但一些特殊药物如抗肿瘤药物紫杉醇、抗真菌药物氟康唑等能够增加其溶出量,溶解出的DEHP随药液进入人体。
    美国食品药品管理局规定含DEHP的PVC输液器须明确标识,并劝告卫生专业人员使用不含DEHP的替代品。环境保护部门和一些民间组织呼吁禁止使用PVC输液器;欧盟:2007年1月起禁止使用用DEHP增塑的PVC输液器。
    我国在注射液包装和食品包装方面已经限制使用PVC材料。食品药品监督管理局建议医院在使用多西他赛注射液、紫杉醇注射液、注射用氟康唑、氢化可地松注射液、醋酸泼尼松注射液等用聚氧乙烯蓖麻油和乙醇作增溶剂的药物时选用非PVC输液器。因为聚氧乙烯蓖麻油和乙醇能够增加DEHP的溶出量,对人体产生危害。紫杉醇注射液、尼莫低平注射液说明书中也标注禁止使用PVC输液器。
    PVC材料输液器还具有极性,对安定、硝酸甘油等醇溶性、脂溶性、尤其是抗肿瘤药物具有较强吸附性,可以使处方剂量不准。
    临床医护人员应了解各种输液器的材质结构特点,根据药物本身和附加剂的理化性质,以及患者的自身状况合理选择输液器,保证治疗安全,降低毒副反应发生。
    婴儿、孕妇或哺乳妇女、老年人的药代动力学与正常人不同,DEHP在体内滞留时间更长一些,会被代谢成毒性比DEHP更大的物质。因此,不宜长时间大量接触含有DEHP的塑料制品。 
    目前,市场上也有一些非PVC输液器,如标有:TPE、HDPE的输液器,可供选择。另外,一些特殊药物会自带输液器,这种输液器是专门根据药物性质,配合输液制作的,所以要尽量使用这种输液器。
编辑:彭丽华

  • lybrido and lybridos But State Department spokeswoman Marie Harf said later that Kerry, in an interview with CBS News that aired on Sunday, was not specifically referring to Assad royal fern ffxiv reddit This can often mean that by the time an app is ready for publication, the business need or industry landscape may have changed ">·I work for myself generic xanax order online “It’s like at one point every company was happy with just the normal four-legged chair until the roller wheels came in ">·I was made redundant two months ag
  • valium durante el parto For the second part of the study, they looked at children who had been given antibiotics in early life ">·Ive come to collect a parcel
  • valium drug test detection I was literally walking out of the restaurant when the chef said to me, Do you want a job in the kitchen? I said OK, sure. ">·I like watching TV pure cambogia ultra bad side effects The assessment costs Ohio $5.3 million, money that could beused for education, roads and other local needs, the statementsaid ">·What are the hours of work?
  • ·comment6, http://sildenafilkfc.com
  • clemix test complex review Be sure to include your name, daytime phone number, address, name and phone number of legal next-of-kin, method of payment, and the name of the funeral home/crematory to contact for verification of death. ">·Id like , please siesta key beachfront villa rentals The spacecraft is a service module designed to eventually carry a lunar landing craft, but its current mission is to scan the Moon for suitable landing sites for Chinas Change 5 lunar mission planned for 2017. ">·In tens, please (ten pound notes)